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To reduce the potential for overdosage or the event of dependence, Restrict the prescribing and dispensing of sedative-hypnotic barbiturates, to the quantity essential for the interval till the following appointment

pentobarbital will decrease the extent or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Double brexpiprazole dose more than one-two weeks if administered with a powerful CYP3A4 inducer.

pentobarbital will lessen the level or result of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

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pentobarbital will lower the extent or influence of ambrisentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.

pentobarbital will decrease the extent or impact of linagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Use of alternative treatment plans is strongly suggested when linagliptin will be to be administered with a CYP3A4 inducer

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Watch Closely (1)pentobarbital will lower the extent or outcome of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to the decrease in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, enhancement of a withdrawal syndrome within a individual who's got made physical dependence to fentanyl. Following stopping a CYP3A4 inducer, given that the effects on the inducer decrease, the fentanyl plasma concentration will improve which could maximize or lengthen both the therapeutic and adverse effects.

Insignificant (one)pentobarbital will decrease the level or impact of paclitaxel protein certain by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.

pentobarbital will lessen the level or result of armodafinil by affecting hepatic/intestinal enzyme CYP3A4 here metabolism. Slight/Significance Unfamiliar.

pentobarbital will lessen the extent or result of rabeprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.

pentobarbital will lower the level or outcome of efavirenz by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.

buprenorphine transdermal and pentobarbital both increase sedation. Keep away from or Use Alternate Drug. Limit use to sufferers for whom alternate remedy solutions are inadequate